Seroatlas · Human Serome Atlas

NREP

Neuronal regeneration-related protein

Also known as: C5orf13, D4S114, NREP_HUMAN, P311, PRO1873, PTZ17, SEZ17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16612
Gene: NREP
Ensembl: ENSG00000134986
Chromosome: 5
Canonical length: 68 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>Q16612|NREP
     1  MVYYPELFVW VSQEPFPNKD MEGRLPKGRL PVPKEVNRKK NDETNAASLT PLGSSELRSP
    61  RISYLHFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NREP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 420 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 420 nTPM
skeletal muscle: 169 nTPM
thymus: 157 nTPM
placenta: 112 nTPM
tongue: 110 nTPM
cerebral cortex: 102 nTPM

Single-cell type

choroid plexus epithelial cells: 239 nCPM
myonuclei: 207 nCPM
retinal amacrine cells: 182 nCPM
cytotrophoblasts: 176 nCPM
brain excitatory neurons: 173 nCPM
thymocytes: 164 nCPM

Immune cell

plasmacytoid DC: 25 nTPM
myeloid DC: 25 nTPM
NK-cell: 6.9 nTPM
classical monocyte: 4 nTPM
intermediate monocyte: 2.2 nTPM
total PBMC: 2.2 nTPM

Brain region

cerebellum: 238 nTPM
cerebral cortex: 83 nTPM
choroid plexus: 62 nTPM
white matter: 54 nTPM
midbrain: 52 nTPM
hippocampal formation: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0.01
gnomAD missense Z: 0.1
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Neuronal protein 3.1
Neuronal protein 3.1 (p311)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NREP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NREP as an antibody target. Whether an autoantibody or antibody against NREP could matter depends on whether native NREP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NREP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NREP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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