Seroatlas · Human Serome Atlas

NRAC

Nutritionally-regulated adipose and cardiac enriched protein homolog

Also known as: C14orf180, C14orf77, NRAC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N912
Gene
NRAC
Ensembl
ENSG00000184601
Chromosome
14
Canonical length
160 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q8N912|NRAC
     1  MRTAAGAVSP DSRPETRRQT RKNEEAAWGP RVCRAEREDN RKCPPSILKR SRPEHHRPEA
    61  KPQRTSRRVW FREPPAVTVH YIADKNATAT VRVPGRPRPH GGSLLLQLCV CVLLVLALGL
   121  YCGRAKPVAT ALEDLRARLL GLVLHLRHVA LTCWRGLLRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
103 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 103 nTPM
  • choroid plexus: 41 nTPM
  • adipose tissue: 39 nTPM
  • breast: 27 nTPM
  • blood vessel: 17 nTPM
  • skeletal muscle: 5.4 nTPM

Single-cell type

  • choroid plexus epithelial cells: 43 nCPM
  • ependymal cells: 12 nCPM
  • cardiomyocytes: 8.2 nCPM
  • adipocytes: 2.9 nCPM
  • gastric chief cells: 2.2 nCPM
  • epididymal efferent duct ciliated cells: 1.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • hippocampal formation: 3.4 nTPM
  • midbrain: 2.2 nTPM
  • medulla oblongata: 1.8 nTPM
  • thalamus: 1.5 nTPM
  • pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4658
  • Domain of unknown function (DUF4658)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRAC as an antibody target. Whether an autoantibody or antibody against NRAC could matter depends on whether native NRAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRAC is annotated at the cell surface, where native NRAC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NRAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NRAC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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