Seroatlas · Human Serome Atlas

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Also known as: DHQV, DIA6, NMOR2, NQO2_HUMAN, QR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16083
Gene
NQO2
Ensembl
ENSG00000124588
Chromosome
6
Canonical length
231 aa
Protein class
Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>P16083|NQO2
     1  MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNLEPR ATDKDITGTL
    61  SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV
   121  LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC
   181  GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NQO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
177 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 177 nTPM
  • tongue: 136 nTPM
  • liver: 116 nTPM
  • skeletal muscle: 114 nTPM
  • adrenal gland: 109 nTPM
  • choroid plexus: 106 nTPM

Single-cell type

  • neutrophils: 279 nCPM
  • hepatocytes: 268 nCPM
  • proximal tubule cells: 191 nCPM
  • neutrophil progenitors: 125 nCPM
  • enterocytes: 117 nCPM
  • hofbauer cells: 108 nCPM

Immune cell

  • neutrophil: 241 nTPM
  • classical monocyte: 92 nTPM
  • intermediate monocyte: 64 nTPM
  • myeloid DC: 62 nTPM
  • non-classical monocyte: 61 nTPM
  • eosinophil: 53 nTPM

Brain region

  • choroid plexus: 101 nTPM
  • cerebral cortex: 98 nTPM
  • pons: 94 nTPM
  • cerebellum: 93 nTPM
  • medulla oblongata: 78 nTPM
  • white matter: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • quinone catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NQO2 as an antibody target. Whether an autoantibody or antibody against NQO2 could matter depends on whether native NQO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NQO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NQO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NQO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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