NPW
Neuropeptide W
Also known as: NPW_HUMAN, PPL8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N729
- Gene
- NPW
- Ensembl
- ENSG00000183971
- Chromosome
- 16
- Canonical length
- 165 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>Q8N729|NPW
1 MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG LLMGLRRSPY
61 LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE TRRRSSQAGI PVRAPRSPRA
121 PEPALEPESL DFSGAGQRLR RDVSRPAVDP AANRLGLPCL APGPFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NPW can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- liver: 25 nTPM
- pituitary gland: 5.5 nTPM
- testis: 2.7 nTPM
- skin: 2.6 nTPM
- stomach: 2.2 nTPM
- endometrium: 2.1 nTPM
Single-cell type
- neuroendocrine cells: 303 nCPM
- endometrial stromal cells: 140 nCPM
- gastric progenitor cells: 67 nCPM
- foveolar cells: 64 nCPM
- decidual stromal cells: 62 nCPM
- epididymal principal cells: 56 nCPM
Immune cell
- neutrophil: 1.5 nTPM
- basophil: 1.2 nTPM
- classical monocyte: 0.7 nTPM
- eosinophil: 0.7 nTPM
- myeloid DC: 0.7 nTPM
- MAIT T-cell: 0.6 nTPM
Brain region
- cerebral cortex: 8.1 nTPM
- hypothalamus: 5.8 nTPM
- choroid plexus: 2.8 nTPM
- basal ganglia: 2.5 nTPM
- midbrain: 2.3 nTPM
- white matter: 2.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Neuropeptide B/W precursor family
- Neuropeptides B and W
- Neuropeptide W precursor
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NPW as an antibody target. Whether an autoantibody or antibody against NPW could matter depends on whether native NPW is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NPW is annotated as secreted, so native NPW circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label NPW as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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