Seroatlas · Human Serome Atlas

NPVF

Pro-FMRFamide-related neuropeptide VF

Also known as: C7orf9, NPVF_HUMAN, RFRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCQ7
Gene: NPVF
Ensembl: ENSG00000105954
Chromosome: 7
Canonical length: 196 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Enables neuropeptide activity. Involved in negative regulation of gonadotropin secretion and neuropeptide signaling pathway. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q9HCQ7|NPVF
     1  MEIISSKLFI LLTLATSSLL TSNIFCADEL VMSNLHSKEN YDKYSEPRGY PKGERSLNFE
    61  ELKDWGPKNV IKMSTPAVNK MPHSFANLPL RFGRNVQEER SAGATANLPL RSGRNMEVSL
   121  VRRVPNLPQR FGRTTTAKSV CRMLSDLCQG SMHSPCANDL FYSMTCQHQE IQNPDQKQSR
   181  RLLFKKIDDA ELKQEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPVF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 204 nTPM

Expression across tissuesHPA

Tissue

retina: 204 nTPM
hypothalamus: 4.9 nTPM
tonsil: 0.3 nTPM
pituitary gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

müller glia: 335 nCPM
rod photoreceptor cells: 2.7 nCPM
retinal horizontal cells: 2 nCPM
retinal bipolar cells: 0.5 nCPM
neutrophils: 0.2 nCPM
cardiomyocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 7.3 nTPM
midbrain: 0.4 nTPM
cerebral cortex: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.6
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

FMRFamide-related peptide/Growth hormone-releasing peptide

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPVF as an antibody target. Whether an autoantibody or antibody against NPVF could matter depends on whether native NPVF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPVF is annotated as secreted, so native NPVF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPVF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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