Seroatlas · Human Serome Atlas

NPSR1

Neuropeptide S receptor

Also known as: GPR154, GPRA, NPSR1_HUMAN, PGR14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6W5P4
Gene
NPSR1
Ensembl
ENSG00000187258
Chromosome
7
Canonical length
371 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q6W5P4|NPSR1
     1  MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF
    61  VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV
   121  CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQARVLIVIA WSLSFLFSIP
   181  TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK
   241  SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN
   301  LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CREQRSQDSR MTFRERTERH
   361  EMQILSKPEF I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
0.4 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 0.4 nTPM
  • hypothalamus: 0.3 nTPM
  • testis: 0.2 nTPM
  • choroid plexus: 0.1 nTPM
  • colon: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • foveolar cells: 44 nCPM
  • brain inhibitory neurons: 32 nCPM
  • early spermatids: 20 nCPM
  • gastric progenitor cells: 17 nCPM
  • other brain neurons: 14 nCPM
  • brain excitatory neurons: 14 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 4.4 nTPM
  • thalamus: 3.8 nTPM
  • midbrain: 3.5 nTPM
  • basal ganglia: 2.1 nTPM
  • medulla oblongata: 1.9 nTPM
  • hippocampal formation: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
-0.38
DepMap mean gene effect
0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPSR1 as an antibody target. Whether an autoantibody or antibody against NPSR1 could matter depends on whether native NPSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPSR1 is annotated at the cell surface, where native NPSR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPSR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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