NPS

Protein identityUniProt · HPA

UniProt accession

P0C0P6

Gene

NPS

Ensembl

ENSG00000214285

Chromosome

10

Canonical length

89 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted in brain

OverviewNCBI Gene

Predicted to be involved in positive regulation of GABAergic synaptic transmission; positive regulation of action potential; and positive regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within visual learning. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>P0C0P6|NPS
     1  MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD RSKELAFLKP
    61  ILEKMFVKRS FRNGVGTGMK KTSFQRAKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.61

Highest tissue expression

0 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for NPS from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.92

gnomAD pLI

0

gnomAD missense Z

-0.53

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• neuropeptide signaling pathway
• positive regulation of action potential
• positive regulation of circadian sleep/wake cycle, wakefulness
• positive regulation of synaptic transmission, GABAergic
• positive regulation of synaptic transmission, glutamatergic
• synaptic transmission, glutamatergic
• visual learning

Cellular components

• extracellular region
• synapse

Protein domainsUniProt · Pfam · InterPro

• Neuropeptide S
• Neuropeptide S precursor protein

KeywordsUniProt

• Cleavage on pair of basic residues
• Neuropeptide
• Secreted
• Signal