Seroatlas · Human Serome Atlas

NPPC

C-type natriuretic peptide

Also known as: ANFC_HUMAN, CNP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P23582
Gene: NPPC
Ensembl: ENSG00000163273
Chromosome: 2
Canonical length: 126 aa
Protein class: Predicted secreted proteins, Transporters
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>P23582|NPPC
     1  MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG
    61  GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS
   121  MSGLGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 7.6 nTPM
heart muscle: 4.8 nTPM
hypothalamus: 4.7 nTPM
hippocampal formation: 4.5 nTPM
cerebral cortex: 4.4 nTPM
prostate: 4 nTPM

Single-cell type

epididymal basal cells: 73 nCPM
pdcs: 45 nCPM
brain inhibitory neurons: 40 nCPM
esophageal basal cells: 29 nCPM
epididymal clear cells: 25 nCPM
müller glia: 21 nCPM

Immune cell

myeloid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 76 nTPM
spinal cord: 72 nTPM
white matter: 16 nTPM
thalamus: 13 nTPM
hypothalamus: 12 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0.06
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPPC as an antibody target. Whether an autoantibody or antibody against NPPC could matter depends on whether native NPPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPPC is annotated as secreted, so native NPPC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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