Seroatlas · Human Serome Atlas

NPPA

Natriuretic peptides A

Also known as: ANF_HUMAN, ANP, PND

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01160
Gene
NPPA
Ensembl
ENSG00000175206
Chromosome
1
Canonical length
151 aa
Protein class
Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>P01160|NPPA
     1  MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP
    61  QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG PWDSSDRSAL LKSKLRALLT
   121  APRSLRRSSC FGGRMDRIGA QSGLGCNSFR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPPA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
57,628 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 57,628 nTPM
  • pancreas: 65 nTPM
  • blood vessel: 30 nTPM
  • salivary gland: 27 nTPM
  • breast: 15 nTPM
  • cerebral cortex: 13 nTPM

Single-cell type

  • epididymal principal cells: 21 nCPM
  • platelets: 13 nCPM
  • epicardial cells: 9.1 nCPM
  • early spermatids: 5.4 nCPM
  • late primary spermatocytes: 4.2 nCPM
  • retinal horizontal cells: 4 nCPM

Immune cell

  • memory B-cell: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebral cortex: 3.6 nTPM
  • choroid plexus: 3.4 nTPM
  • white matter: 2.5 nTPM
  • cerebellum: 2.2 nTPM
  • basal ganglia: 2.1 nTPM
  • hypothalamus: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NPPA.

Disease | AllUniProt

Conditions NPPA is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Atrial fibrillation, familial, 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
gnomAD missense Z
-0.27
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPPA as an antibody target. Whether an autoantibody or antibody against NPPA could matter depends on whether native NPPA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPPA is annotated as secreted, so native NPPA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPPA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPPA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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