NPEPPSL1
Puromycin-sensitive aminopeptidase-like protein
Also known as: PSAL_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for NPEPPSL1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
478 residues, UniProt reviewed canonical sequence.
>A6NEC2|NPEPPSL1
1 MWLAAAAPSL ARRLLFLGPP PPPLLLLVFS RSSRRRLHSL GLAAMPEKRP FERLPADVSP
61 INCSLCLKPD LLDFTFEGKL EAAAQVRQAT NQIVMNCADI DIITASYAPE GDEEIHATGF
121 NYQNEDEKVT LSFPSTLQTG TGTLKIDFVG ELNDKMKGFY RSKYTTPSGE VRYAAVTQFE
181 ATDARRAFPC WDERAIKATF DISLVVPKDR VALSNMNVID RKPYPDDENL VEVKFARTPV
241 TSTYLVAFVV GEYDFVETRS KDGVCVCVYT PVGKAEQGKF ALEVAAKTLP FYKDYFNVPY
301 PLPKIDLIAI ADFAAGAMEN WDLVTYRETA LLIDPKNSCS SSRQWVALVV GHELAHQWFG
361 NLVTMEWWTH LRLNEGFASW IEYLCVDHCF PEYDIWTQFV SADYTRAQEL DALDNSHPIE
421 VSVGHPSEVD EIFDAISYSK GASVIRMLHD YIGDKDFKKG MNMYLTKFQQ KNAAAGNLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NPEPPSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
- Peptidase M1, membrane alanine aminopeptidase
- Peptidase M4/M1, CTD superfamily
- Aminopeptidase N-type
- Aminopeptidase N-like , N-terminal domain superfamliy
- Aminopeptidase N-like , N-terminal domain
- Peptidase M1 family aminopeptidases
- Peptidase family M1 domain
- Peptidase M1 N-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NPEPPSL1 as an antibody target. Whether an autoantibody or antibody against NPEPPSL1 could matter depends on whether native NPEPPSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NPEPPSL1 is annotated as secreted, so native NPEPPSL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label NPEPPSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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