NPDC1
Neural proliferation differentiation and control protein 1
Also known as: CAB-, CAB1, DKFZp586J0523, NPDC1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NQX5
- Gene
- NPDC1
- Ensembl
- ENSG00000107281
- Chromosome
- 9
- Canonical length
- 325 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
325 residues, UniProt reviewed canonical sequence.
>Q9NQX5|NPDC1
1 MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA
61 HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK
121 DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG
181 DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ
241 RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME
301 VRNPLFDHAA LSAPLPAPSS PPALPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NPDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 318 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 318 nTPM
- pituitary gland: 260 nTPM
- prostate: 255 nTPM
- cerebral cortex: 207 nTPM
- hypothalamus: 196 nTPM
- hippocampal formation: 182 nTPM
Single-cell type
- gastric chief cells: 104 nCPM
- breast lactating cells: 84 nCPM
- mucous neck cells: 82 nCPM
- prostatic glandular cells: 74 nCPM
- vascular endothelial cells: 69 nCPM
- goblet cells: 47 nCPM
Immune cell
- memory CD4 T-cell: 19 nTPM
- memory CD8 T-cell: 19 nTPM
- T-reg: 16 nTPM
- MAIT T-cell: 15 nTPM
- gdT-cell: 12 nTPM
- plasmacytoid DC: 3.4 nTPM
Brain region
- midbrain: 220 nTPM
- thalamus: 220 nTPM
- hypothalamus: 216 nTPM
- cerebral cortex: 213 nTPM
- amygdala: 212 nTPM
- hippocampal formation: 212 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Neural proliferation differentiation control-1
- Neural proliferation differentiation control-1 protein (NPDC1)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NPDC1 as an antibody target. Whether an autoantibody or antibody against NPDC1 could matter depends on whether native NPDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NPDC1 is annotated at the cell surface, where native NPDC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NPDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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