Seroatlas · Human Serome Atlas

NPBWR2

Neuropeptides B/W receptor type 2

Also known as: GPR8, NPBW2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48146
Gene: NPBWR2
Ensembl: ENSG00000125522
Chromosome: 20
Canonical length: 333 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>P48146|NPBWR2
     1  MQAAGHPEPL DSRGSFSLPT MGANVSQDNG TGHNATFSEP LPFLYVLLPA VYSGICAVGL
    61  TGNTAVILVI LRAPKMKTVT NVFILNLAVA DGLFTLVLPV NIAEHLLQYW PFGELLCKLV
   121  LAVDHYNIFS SIYFLAVMSV DRYLVVLATV RSRHMPWRTY RGAKVASLCV WLGVTVLVLP
   181  FFSFAGVYSN ELQVPSCGLS FPWPEQVWFK ASRVYTLVLG FVLPVCTICV LYTDLLRRLR
   241  AVRLRSGAKA LGKARRKVTV LVLVVLAVCL LCWTPFHLAS VVALTTDLPQ TPLVISMSYV
   301  ITSLSYANSC LNPFLYAFLD DNFRKNFRSI LRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPBWR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 0.2 nTPM
cerebral cortex: 0.1 nTPM
adipose tissue: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 5.8 nTPM
white matter: 2.9 nTPM
cerebellum: 0.6 nTPM
hypothalamus: 0.6 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPBWR2 as an antibody target. Whether an autoantibody or antibody against NPBWR2 could matter depends on whether native NPBWR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPBWR2 is annotated at the cell surface, where native NPBWR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPBWR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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