Seroatlas · Human Serome Atlas

NPBWR1

Neuropeptides B/W receptor type 1

Also known as: GPR7, NPBW1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48145
Gene: NPBWR1
Ensembl: ENSG00000288611
Chromosome: 8
Canonical length: 328 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>P48145|NPBWR1
     1  MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV GLAGNSAVLY
    61  VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR QWPFGELMCK LIVAIDQYNT
   121  FSSLYFLTVM SADRYLVVLA TAESRRVAGR TYSAARAVSL AVWGIVTLVV LPFAVFARLD
   181  DEQGRRQCVL VFPQPEAFWW RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK
   241  ALERAKKRVT FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS
   301  CLNPFLYAFL DASFRRNLRQ LITCRAAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPBWR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

liver: 2.4 nTPM
cerebral cortex: 1 nTPM
gallbladder: 0.9 nTPM
hypothalamus: 0.7 nTPM
cervix: 0.4 nTPM
pituitary gland: 0.4 nTPM

Single-cell type

respiratory basal cells: 2.4 nCPM
cholangiocytes: 2 nCPM
other brain neurons: 1.5 nCPM
hepatocytes: 1.2 nCPM
submucosal glandular cells: 1.2 nCPM
salivary basal cells: 0.9 nCPM

Immune cell

eosinophil: 0.7 nTPM
classical monocyte: 0.3 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 3.6 nTPM
medulla oblongata: 2.3 nTPM
cerebral cortex: 2.2 nTPM
basal ganglia: 2.1 nTPM
thalamus: 1.4 nTPM
midbrain: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.71
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPBWR1 as an antibody target. Whether an autoantibody or antibody against NPBWR1 could matter depends on whether native NPBWR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPBWR1 is annotated at the cell surface, where native NPBWR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPBWR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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