Seroatlas · Human Serome Atlas

NPB

Neuropeptide B

Also known as: NPB_HUMAN, PPL7, PPNPB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG41
Gene: NPB
Ensembl: ENSG00000183979
Chromosome: 17
Canonical length: 125 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q8NG41|NPB
     1  MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS PYARRSQPYR
    61  GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL PDGRGTYQCK ANVFLSLRAA
   121  DCLAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 16 nTPM
hypothalamus: 10 nTPM
midbrain: 7.4 nTPM
basal ganglia: 4.9 nTPM
amygdala: 4.8 nTPM
cerebral cortex: 3.3 nTPM

Single-cell type

syncytiotrophoblasts: 161 nCPM
undifferentiated spermatogonia: 58 nCPM
differentiating spermatogonia: 28 nCPM
early primary spermatocytes: 14 nCPM
epicardial cells: 14 nCPM
other brain neurons: 11 nCPM

Immune cell

eosinophil: 0.4 nTPM
MAIT T-cell: 0.4 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 19 nTPM
hypothalamus: 16 nTPM
midbrain: 13 nTPM
medulla oblongata: 13 nTPM
pons: 11 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPB as an antibody target. Whether an autoantibody or antibody against NPB could matter depends on whether native NPB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPB is annotated as secreted, so native NPB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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