Seroatlas · Human Serome Atlas

NOX5

NADPH oxidase 5

Also known as: NOX5_HUMAN, NOX5A, NOX5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PH1
Gene
NOX5
Ensembl
ENSG00000255346
Chromosome
15
Canonical length
765 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables proton channel activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including endothelial cell proliferation; proton transmembrane transport; and superoxide anion generation. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q96PH1|NOX5
     1  MNTSGDPAQT GPEGCRGTMS AEEDARWLRW VTQQFKTIAG EDGEISLQEF KAALHVKESF
    61  FAERFFALFD SDRSGTITLQ ELQEALTLLI HGSPMDKLKF LFQVYDIDVC ARQGASAGTE
   121  WGAGAGPHWA SSPLGTGSGS IDPDELRTVL QSCLRESAIS LPDEKLDQLT LALFESADAD
   181  GNGAITFEEL RDELQRFPGV MENLTISAAH WLTAPAPRPR PRRPRQLTRA YWHNHRSQLF
   241  CLATYAGLHV LLFGLAASAH RDLGASVMVA KGCGQCLNFD CSFIAVLMLR RCLTWLRATW
   301  LAQVLPLDQN IQFHQLMGYV VVGLSLVHTV AHTVNFVLQA QAEASPFQFW ELLLTTRPGI
   361  GWVHGSASPT GVALLLLLLL MFICSSSCIR RSGHFEVFYW THLSYLLVWL LLIFHGPNFW
   421  KWLLVPGILF FLEKAIGLAV SRMAAVCIME VNLLPSKVTH LLIKRPPFFH YRPGDYLYLN
   481  IPTIARYEWH PFTISSAPEQ KDTIWLHIRS QGQWTNRLYE SFKASDPLGR GSKRLSRSVT
   541  MRKSQRSSKG SEILLEKHKF CNIKCYIDGP YGTPTRRIFA SEHAVLIGAG IGITPFASIL
   601  QSIMYRHQKR KHTCPSCQHS WIEGVQDNMK LHKVDFIWIN RDQRSFEWFV SLLTKLEMDQ
   661  AEEAQYGRFL ELHMYMTSAL GKNDMKAIGL QMALDLLANK EKKDSITGLQ TRTQPGRPDW
   721  SKVFQKVAAE KKGKVQVFFC GSPALAKVLK GHCEKFGFRF FQENF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
8.1 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 8.1 nTPM
  • cervix: 1 nTPM
  • testis: 0.8 nTPM
  • smooth muscle: 0.7 nTPM
  • epididymis: 0.6 nTPM
  • prostate: 0.3 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 7.7 nCPM
  • renal collecting duct principal cells: 5.6 nCPM
  • podocytes: 4.4 nCPM
  • proximal tubule cells: 4.3 nCPM
  • loop of henle epithelial cells: 4 nCPM
  • renal connecting tubule cells: 3.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0.4 nTPM
  • basal ganglia: 0.4 nTPM
  • cerebral cortex: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOX5 as an antibody target. Whether an autoantibody or antibody against NOX5 could matter depends on whether native NOX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOX5 is annotated at the cell surface, where native NOX5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NOX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NOX5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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