Seroatlas · Human Serome Atlas

NOTUM

Palmitoleoyl-protein carboxylesterase NOTUM

Also known as: NOTUM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P988
Gene
NOTUM
Ensembl
ENSG00000185269
Chromosome
17
Canonical length
496 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Secreted in female reproductive system

OverviewNCBI Gene

Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q6P988|NOTUM
     1  MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE
    61  GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW
   121  LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI
   181  PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL
   241  NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG
   301  VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH LTGQPVQEGL
   361  RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV QVKGTSLPRA LHCWDRSLHD
   421  SHKASKTPLK GCPVHLVDSC PWPHCNPSCP TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP
   481  QGLEPSELLG MLSNGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOTUM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 128 nTPM
  • liver: 11 nTPM
  • skeletal muscle: 7.7 nTPM
  • testis: 2.8 nTPM
  • kidney: 2.1 nTPM
  • skin: 2.1 nTPM

Single-cell type

  • extravillous trophoblasts: 1,955 nCPM
  • epididymal efferent duct absorptive cells: 44 nCPM
  • myonuclei: 27 nCPM
  • differentiating spermatogonia: 14 nCPM
  • paneth cells: 12 nCPM
  • thymic myoid cells: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 5.7 nTPM
  • basal ganglia: 4.4 nTPM
  • cerebral cortex: 4 nTPM
  • medulla oblongata: 4 nTPM
  • amygdala: 3.8 nTPM
  • thalamus: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0
gnomAD missense Z
1.44
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Pectinacetylesterase/NOTUM
  • Pectinacetylesterase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOTUM as an antibody target. Whether an autoantibody or antibody against NOTUM could matter depends on whether native NOTUM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOTUM is annotated as secreted, so native NOTUM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NOTUM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NOTUM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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