Seroatlas · Human Serome Atlas

NOL7

U3 small nucleolar RNA-associated protein NOL7

Also known as: C6orf90, dJ223E5.2, NOP27, PQBP3, RARG-1, UTP16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UMY1
Gene: NOL7
Ensembl: ENSG00000225921
Chromosome: 6
Canonical length: 257 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitotic chromosome,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q9UMY1|NOL7
     1  MVQLRPRASR APASAEAMVD EGQLASEEEE AEHGLLLGQP SSGAAAEPLE EDEEGDDEFD
    61  DEAPEELTFA SAQAEAREEE RRVRETVRRD KTLLKEKRKR REELFIEQKK RKLLPDTILE
   121  KLTTASQTNI KKSPGKVKEV NLQKKNEDCE KGNDSKKVKV QKVQSVSQNK SYLAVRLKDQ
   181  DLRDSRQQAA QAFIHNSLYG PGTNRTTVNK FLSLANKRLP VKRAAVQFLN NAWGIQKKQN
   241  AKRFKRRWMV RKMKTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 48 nTPM
kidney: 42 nTPM
amygdala: 41 nTPM
midbrain: 41 nTPM
cerebral cortex: 39 nTPM
parathyroid gland: 38 nTPM

Single-cell type

late primary spermatocytes: 348 nCPM
gastric progenitor cells: 247 nCPM
megakaryocytes: 241 nCPM
syncytiotrophoblasts: 215 nCPM
esophageal basal cells: 210 nCPM
migrating cytotrophoblasts: 208 nCPM

Immune cell

memory B-cell: 104 nTPM
T-reg: 96 nTPM
plasmacytoid DC: 92 nTPM
naive CD4 T-cell: 91 nTPM
naive B-cell: 88 nTPM
memory CD4 T-cell: 85 nTPM

Brain region

white matter: 33 nTPM
cerebellum: 31 nTPM
midbrain: 30 nTPM
medulla oblongata: 29 nTPM
hypothalamus: 29 nTPM
pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.86
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

U3 small nucleolar RNA-associated protein NOL7, C-terminal
NUC129 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOL7 as an antibody target. Whether an autoantibody or antibody against NOL7 could matter depends on whether native NOL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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