Seroatlas · Human Serome Atlas

NOL10

Nucleolar protein 10

Also known as: FLJ14075, NOL10_HUMAN, PQBP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSC4
Gene: NOL10
Ensembl: ENSG00000115761
Chromosome: 2
Canonical length: 688 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>Q9BSC4|NOL10
     1  MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKDVDVR RRIELIQDFE MPTVCTTIKV
    61  SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF EILSDDYSKI VFLHNDRYIE
   121  FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY FVGASSEVYR LNLEQGRYLN PLQTDAAENN
   181  VCDINSVHGL FATGTIEGRV ECWDPRTRNR VGLLDCALNS VTADSEINSL PTISALKFNG
   241  ALTMAVGTTT GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLILSA DSRIVKMWNK
   301  NSGKIFTSLE PEHDLNDVCL YPNSGMLLTA NETPKMGIYY IPVLGPAPRW CSFLDNLTEE
   361  LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH GFFMDIRLYH KVKLMVNPFA
   421  YEEYRKDKIR QKIEETRAQR VQLKKLPKVN KELALKLIEE EEEKQKSTWK KKVKSLPNIL
   481  TDDRFKVMFE NPDFQVDEES EEFRLLNPLV SKISEKRKKK LRLLEQQELR EKEEEEEPEG
   541  KPSDAESSES SDDEKAWVEE VRKQRRLLQQ EEKVKRQERL KEDQQTVLKP QFYEIKAGEE
   601  FRSFKDSATK QKLMNKTLED RLKIEAKNGT LSVSDTTVGS KQLTFTLKRS EQQKKQQEAE
   661  KLHRQERKRL RRSAGHLKSR HKRGRSFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 14 nTPM
pancreas: 12 nTPM
adrenal gland: 11 nTPM
liver: 11 nTPM
esophagus: 9.8 nTPM
testis: 9.5 nTPM

Single-cell type

late spermatids: 230 nCPM
late primary spermatocytes: 174 nCPM
early spermatids: 168 nCPM
adrenal cortex cells: 154 nCPM
myonuclei: 140 nCPM
pancreatic acinar cells: 137 nCPM

Immune cell

T-reg: 1.3 nTPM
intermediate monocyte: 0.8 nTPM
myeloid DC: 0.6 nTPM
gdT-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
classical monocyte: 0.3 nTPM

Brain region

cerebellum: 2.4 nTPM
cerebral cortex: 2.4 nTPM
thalamus: 2.4 nTPM
white matter: 2.4 nTPM
basal ganglia: 2.2 nTPM
hypothalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.05
gnomAD missense Z: 1.15
DepMap mean gene effect: -1.32
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

LSU-rRNA)
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
NUC153
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
NUC153 domain
Nucleolar protein 10/Enp2
Nucleolar protein 10-like, second domain
Nucleolar protein 10-like, N-terminal domain
Nucleolar protein 10-like, second domain
Nucleolar protein 10-like, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOL10 as an antibody target. Whether an autoantibody or antibody against NOL10 could matter depends on whether native NOL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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