NNAT
Neuronatin
Also known as: NNAT_HUMAN, Peg5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q16517
- Gene
- NNAT
- Ensembl
- ENSG00000053438
- Chromosome
- 20
- Canonical length
- 81 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
OverviewNCBI Gene
The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of another gene, bladder cancer associated protein, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. [provided by RefSeq, Apr 2016]
Canonical amino-acid sequenceUniProt
81 residues, UniProt reviewed canonical sequence.
>Q16517|NNAT
1 MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL
61 AYTVSRTGRQ VLGERRQRAP NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NNAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 1,529 nTPM
Expression across tissuesHPA
Tissue
- pituitary gland: 1,529 nTPM
- basal ganglia: 914 nTPM
- amygdala: 283 nTPM
- hippocampal formation: 252 nTPM
- hypothalamus: 199 nTPM
- cerebral cortex: 182 nTPM
Single-cell type
- corticotrophs: 863 nCPM
- somatotrophs: 537 nCPM
- ependymal cells: 321 nCPM
- epididymal efferent duct ciliated cells: 294 nCPM
- lactotrophs: 220 nCPM
- medullary thymic epithelial cells: 175 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 301 nTPM
- amygdala: 233 nTPM
- hippocampal formation: 229 nTPM
- hypothalamus: 199 nTPM
- cerebral cortex: 140 nTPM
- choroid plexus: 125 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.94
- gnomAD pLI
- 0.4
- gnomAD missense Z
- 0.75
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Neuronatin
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NNAT as an antibody target. Whether an autoantibody or antibody against NNAT could matter depends on whether native NNAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NNAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NNAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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