Seroatlas · Human Serome Atlas

NMUR2

Neuromedin-U receptor 2

Also known as: NMU2R, NMUR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZQ4
Gene: NMUR2
Ensembl: ENSG00000132911
Chromosome: 5
Canonical length: 415 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q9GZQ4|NMUR2
     1  MSGMEKLQNA SWIYQQKLED PFQKHLNSTE EYLAFLCGPR RSHFFLPVSV VYVPIFVVGV
    61  IGNVLVCLVI LQHQAMKTPT NYYLFSLAVS DLLVLLLGMP LEVYEMWRNY PFLFGPVGCY
   121  FKTALFETVC FASILSITTV SVERYVAILH PFRAKLQSTR RRALRILGIV WGFSVLFSLP
   181  NTSIHGIKFH YFPNGSLVPG SATCTVIKPM WIYNFIIQVT SFLFYLLPMT VISVLYYLMA
   241  LRLKKDKSLE ADEGNANIQR PCRKSVNKML FVLVLVFAIC WAPFHIDRLF FSFVEEWSES
   301  LAAVFNLVHV VSGVFFYLSS AVNPIIYNLL SRRFQAAFQN VISSFHKQWH SQHDPQLPPA
   361  QRNIFLTECH FVELTEDIGP QFPCQSSMHN SHLPAALSSE QMSRTNYQSF HFNKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMUR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

testis: 1.5 nTPM
stomach: 1 nTPM
hypothalamus: 0.7 nTPM
spinal cord: 0.7 nTPM
kidney: 0.5 nTPM
thymus: 0.5 nTPM

Single-cell type

cardiomyocytes: 22 nCPM
foveolar cells: 21 nCPM
sertoli cells: 17 nCPM
oligodendrocytes: 12 nCPM
gastric progenitor cells: 10 nCPM
myonuclei: 9.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 13 nTPM
medulla oblongata: 9.9 nTPM
pons: 8.8 nTPM
spinal cord: 8.8 nTPM
basal ganglia: 7.5 nTPM
thalamus: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Neuromedin U receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Neuromedin U receptor, type 2
Neuromedin-U receptor 2, C-terminal domain
Neuromedin-U receptor 2, C-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMUR2 as an antibody target. Whether an autoantibody or antibody against NMUR2 could matter depends on whether native NMUR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMUR2 is annotated at the cell surface, where native NMUR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NMUR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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