Seroatlas · Human Serome Atlas

NMUR1

Neuromedin-U receptor 1

Also known as: FM-3, GPC-R, GPR66, NMU1R, NMUR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB89
Gene: NMUR1
Ensembl: ENSG00000171596
Chromosome: 2
Canonical length: 426 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including calcium-mediated signaling; chloride transport; and positive regulation of calcium-mediated signaling. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q9HB89|NMUR1
     1  MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK YLGPQQTELF
    61  MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF SLAVSDLLVL LVGLPLELYE
   121  MWHNYPFLLG VGGCYFRTLL FEMVCLASVL NVTALSVERY VAVVHPLQAR SMVTRAHVRR
   181  VLGAVWGLAM LCSLPNTSLH GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF
   241  CLPMAIMSVL YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF
   301  VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA ANPVLYSLMS
   361  SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD VGSLGSWVHP LAGNDGPEAQ
   421  QETDPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMUR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

retina: 7.6 nTPM
adipose tissue: 4.9 nTPM
pancreas: 3.9 nTPM
spleen: 3.5 nTPM
small intestine: 3.4 nTPM
lung: 2.9 nTPM

Single-cell type

nk-cells: 36 nCPM
rod photoreceptor cells: 31 nCPM
peritubular myoid cells: 10 nCPM
adipocytes: 7.3 nCPM
innate lymphoid cells: 6.8 nCPM
early primary spermatocytes: 5.8 nCPM

Immune cell

gdT-cell: 18 nTPM
NK-cell: 11 nTPM
memory CD8 T-cell: 8.7 nTPM
naive CD8 T-cell: 5.1 nTPM
total PBMC: 4.8 nTPM
MAIT T-cell: 4.5 nTPM

Brain region

cerebellum: 5 nTPM
cerebral cortex: 3.5 nTPM
basal ganglia: 3 nTPM
white matter: 2.7 nTPM
amygdala: 2.5 nTPM
hippocampal formation: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Neuromedin U receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Neuromedin U receptor, type 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMUR1 as an antibody target. Whether an autoantibody or antibody against NMUR1 could matter depends on whether native NMUR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMUR1 is annotated at the cell surface, where native NMUR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NMUR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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