Seroatlas · Human Serome Atlas

NMS

Neuromedin-S

Also known as: NMS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H8A3
Gene: NMS
Ensembl: ENSG00000204640
Chromosome: 2
Canonical length: 153 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q5H8A3|NMS
     1  MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL SQWAPLSRQP
    61  KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK LANRRMKRIL QRGSGTAAVD
   121  FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ IQW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 1 nTPM
spinal cord: 0.4 nTPM
testis: 0.3 nTPM
tongue: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

early spermatids: 2.2 nCPM
other brain neurons: 1.6 nCPM
foveolar cells: 1 nCPM
neuroendocrine cells: 0.5 nCPM
thyrotrophs: 0.3 nCPM
b-cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 5.7 nTPM
spinal cord: 3.6 nTPM
hypothalamus: 2 nTPM
white matter: 1.5 nTPM
thalamus: 1.1 nTPM
pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neuropeptide signaling pathway

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Neuromedin U, amidation site
Neuromedin S

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMS as an antibody target. Whether an autoantibody or antibody against NMS could matter depends on whether native NMS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMS is annotated as secreted, so native NMS circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NMS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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