NME6

Protein identityUniProt · HPA

UniProt accession

O75414

Gene

NME6

Ensembl

ENSG00000172113

Chromosome

3

Canonical length

186 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>O75414|NME6
     1  MASILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRMRELL WRKEDCQRFY
    61  REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG PTRVFRARHV APDSIRGSFG
   121  LTDTRNTTHG SDSVVSASRE IAAFFPDFSE QRWYEEEEPQ LRCGPVCYSP EGGVHYVAGT
   181  GGLGPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NME6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

17 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.36

gnomAD pLI

0

gnomAD missense Z

0.26

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• CTP biosynthetic process
• GTP biosynthetic process
• negative regulation of cell growth
• negative regulation of mitotic nuclear division
• nucleotide metabolic process
• UTP biosynthetic process
• pyrimidine ribonucleotide salvage

Molecular functions

• ATP binding
• metal ion binding
• nucleoside diphosphate kinase activity

Cellular components

• mitochondrial inner membrane
• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Nucleoside diphosphate kinase
• Nucleoside diphosphate kinase, active site
• Nucleoside diphosphate kinase-like domain
• Nucleoside diphosphate kinase-like domain superfamily
• Nucleoside diphosphate kinase
• Nucleoside diphosphate kinase 6

KeywordsUniProt

• Apoptosis
• ATP-binding
• Kinase
• Magnesium
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion inner membrane
• Nucleotide metabolism
• Nucleotide-binding
• Transferase

InteractionsUniProt · HPA

Protein binding partners of NME6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RCC1L