Seroatlas · Human Serome Atlas

NME2P1

Putative nucleoside diphosphate kinase

Also known as: NDK8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60361
Gene: NME2P1
Canonical length: 137 aa

OverviewNCBI Gene

No narrative summary is available for NME2P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>O60361|NME2P1
     1  MQCGLVGKII KRFEQKGFRL VAMKFLPASE EHLKQHYIDL KDRPFFPGLV KYMNSGPVVA
    61  MVWEGLNVVK TGRVMLGETN PADSKPGTIR GDFCIQVGRN IIHGSDSVKS AEKEISLRFK
   121  PEELVDYKSC AHDWVYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NME2P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NME2P1 as an antibody target. Whether an autoantibody or antibody against NME2P1 could matter depends on whether native NME2P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NME2P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NME2P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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