Seroatlas · Human Serome Atlas

NMBR

Neuromedin-B receptor

Also known as: BB1, BB1R, BRS1, NMBR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28336
Gene
NMBR
Ensembl
ENSG00000135577
Chromosome
6
Canonical length
390 aa
Protein class
G-protein coupled receptors, Plasma proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>P28336|NMBR
     1  MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY LLIITVGLLG
    61  NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWM FGKVGCKLIP
   121  VIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGALLRT CVKAMGIWVV SVLLAVPEAV
   181  FSEVARISSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI
   241  KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL
   301  GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG TSYLLSSSAV
   361  RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMBR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • fallopian tube: 0.4 nTPM
  • hypothalamus: 0.4 nTPM
  • amygdala: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM

Single-cell type

  • respiratory ciliated cells: 24 nCPM
  • late primary spermatocytes: 20 nCPM
  • early primary spermatocytes: 16 nCPM
  • ependymal cells: 11 nCPM
  • adrenal medulla cells: 11 nCPM
  • other brain neurons: 9.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 2 nTPM
  • hypothalamus: 1.7 nTPM
  • medulla oblongata: 1.5 nTPM
  • spinal cord: 1.5 nTPM
  • midbrain: 1.4 nTPM
  • basal ganglia: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
-0.8
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMBR as an antibody target. Whether an autoantibody or antibody against NMBR could matter depends on whether native NMBR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMBR is annotated at the cell surface, where native NMBR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NMBR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NMBR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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