Seroatlas · Human Serome Atlas

NMB

Neuromedin-B

Also known as: MGC17211, MGC2277, MGC3936, NMB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08949
Gene: NMB
Ensembl: ENSG00000197696
Chromosome: 15
Canonical length: 121 aa
Protein class: Predicted secreted proteins
Subcellular location: Golgi apparatus,Plasma membrane,Focal adhesion sites,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>P08949|NMB
     1  MARRAGGARM FGSLLLFALL AAGVAPLSWD LPEPRSRASK IRVHSRGNLW ATGHFMGKKS
    61  LEPSSPSPLG TAPHTSLRDQ RLQLSHDLLG ILLLKKALGV SLSRPAPQIQ YRRLLVQILQ
   121  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 76 nTPM
breast: 50 nTPM
hypothalamus: 41 nTPM
cerebral cortex: 40 nTPM
adrenal gland: 38 nTPM
choroid plexus: 30 nTPM

Single-cell type

pancreatic duct cells: 152 nCPM
epididymal basal cells: 90 nCPM
gastric progenitor cells: 73 nCPM
late primary spermatocytes: 66 nCPM
epididymal efferent duct absorptive cells: 61 nCPM
urothelial cells: 58 nCPM

Immune cell

plasmacytoid DC: 13 nTPM
naive B-cell: 11 nTPM
gdT-cell: 7.9 nTPM
eosinophil: 7.8 nTPM
memory CD8 T-cell: 7.7 nTPM
T-reg: 7.6 nTPM

Brain region

hypothalamus: 104 nTPM
white matter: 69 nTPM
medulla oblongata: 40 nTPM
pons: 33 nTPM
midbrain: 26 nTPM
spinal cord: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.02
gnomAD missense Z: -0.23
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hormone activity
neuropeptide hormone activity
neuromedin B receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMB as an antibody target. Whether an autoantibody or antibody against NMB could matter depends on whether native NMB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMB is annotated as secreted, so native NMB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NMB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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