NLRP2B
NLR family pyrin domain-containing protein 2B
Also known as: CLRX.1, NALP2P, NLRP2P, NOD24, POP4, PYDC4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DMW2
- Gene
- NLRP2B
- Ensembl
- ENSG00000215174
- Chromosome
- X
- Canonical length
- 45 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of peptidyl-serine phosphorylation; and negative regulation of signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
45 residues, UniProt reviewed canonical sequence.
>P0DMW2|NLRP2B
1 MVSSAQLDFN LQALLGQLSQ DDLCKFKSLI RTVSLGNELQ KIPQTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NLRP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 0.2 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 0.2 nTPM
- tongue: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
- liver: 0.1 nTPM
- skeletal muscle: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- leydig cells: 0.6 nCPM
- lymphatic endothelial cells: 0.6 nCPM
- breast secretory cells: 0.5 nCPM
- podocytes: 0.5 nCPM
- adrenal cortex cells: 0.4 nCPM
- bergmann glia: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 1.4 nTPM
- cerebral cortex: 1.3 nTPM
- white matter: 1 nTPM
- medulla oblongata: 0.7 nTPM
- pons: 0.7 nTPM
- basal ganglia: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.96
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- innate immune response
- negative regulation of cell cycle
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of peptidyl-serine phosphorylation
- negative regulation of toll-like receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of apoptotic process
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NLRP2B as an antibody target. Whether an autoantibody or antibody against NLRP2B could matter depends on whether native NLRP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NLRP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NLRP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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