Seroatlas · Human Serome Atlas

NLN

Neurolysin, mitochondrial

Also known as: AGTBP, KIAA1226, NEUL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYT8
Gene: NLN
Ensembl: ENSG00000123213
Chromosome: 5
Canonical length: 704 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

704 residues, UniProt reviewed canonical sequence.

>Q9BYT8|NLN
     1  MIARCLLAVR SLRRVGGSRI LLRMTLGREV MSPLQAMSSY TVAGRNVLRW DLSPEQIKTR
    61  TEELIVQTKQ VYDAVGMLGI EEVTYENCLQ ALADVEVKYI VERTMLDFPQ HVSSDKEVRA
   121  ASTEADKRLS RFDIEMSMRG DIFERIVHLQ ETCDLGKIKP EARRYLEKSI KMGKRNGLHL
   181  PEQVQNEIKS MKKRMSELCI DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKTDDDKYK
   241  ITLKYPHYFP VMKKCCIPET RRRMEMAFNT RCKEENTIIL QQLLPLRTKV AKLLGYSTHA
   301  DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILNL KKKECKDRGF EYDGKINAWD
   361  LYYYMTQTEE LKYSIDQEFL KEYFPIEVVT EGLLNTYQEL LGLSFEQMTD AHVWNKSVTL
   421  YTVKDKATGE VLGQFYLDLY PREGKYNHAA CFGLQPGCLL PDGSRMMAVA ALVVNFSQPV
   481  AGRPSLLRHD EVRTYFHEFG HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDVD
   541  SLRRLSKHYK DGSPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTSLDAASEY
   601  AKYCSEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC FKKEGIMNPE
   661  VGMKYRNLIL KPGGSLDGMD MLHNFLKREP NQKAFLMSRG LHAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

liver: 9.3 nTPM
skeletal muscle: 8.3 nTPM
tongue: 6.1 nTPM
spinal cord: 5.5 nTPM
cerebral cortex: 4.6 nTPM
midbrain: 4.2 nTPM

Single-cell type

hofbauer cells: 71 nCPM
retinal ganglion cells: 66 nCPM
enterocytes: 63 nCPM
myosatellite cells: 60 nCPM
alveolar cells type 1: 60 nCPM
other brain neurons: 60 nCPM

Immune cell

intermediate monocyte: 3.3 nTPM
classical monocyte: 2.6 nTPM
non-classical monocyte: 2.3 nTPM
myeloid DC: 2.2 nTPM
total PBMC: 1 nTPM
NK-cell: 0.5 nTPM

Brain region

cerebral cortex: 11 nTPM
white matter: 11 nTPM
medulla oblongata: 9.5 nTPM
pons: 9.4 nTPM
thalamus: 9.2 nTPM
basal ganglia: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway
peptide metabolic process
proteolysis
regulation of gluconeogenesis
regulation of skeletal muscle fiber differentiation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLN as an antibody target. Whether an autoantibody or antibody against NLN could matter depends on whether native NLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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