Seroatlas · Human Serome Atlas

NKPD1

NTPase KAP family P-loop domain-containing protein 1

Also known as: FLJ33600, NKPD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RQ9
Gene: NKPD1
Ensembl: ENSG00000179846
Chromosome: 19
Canonical length: 610 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q17RQ9|NKPD1
     1  MQQEAAQRES EELQHVQWRP RAVSGWGVPQ LLWYLVFLQP IITEVHLRRR NVQFLFIRFS
    61  AWQYAGTDKL WAGLVTTLCE GIRRHYGALP FSVYSVLGNK PATRQDCCQS EWHCRRRVCL
   121  GLLALLAALG LGVGLLYLSL GGHALGHGSP SGSLLKVFGG AATTLSGSGL LMAVYSVGKH
   181  LFVSQRKKIE RLVSREKFGS QLGFMCEVKK EVELLTDFLC FLEIYQRRRL RVVLEVTGLD
   241  TCYPERVVGV LNAINTLLSD SHAPFIFILV VDPSILAACL ESAGNMKGTA DNGYLFLNRT
   301  VTLPFSVPIM GRRTKLQFLH DAVQSRDDLL YREMTRKPWL PGDAGGESAQ LLAVQAQAGT
   361  ERGQGRIDDE AARRIQEALF CLHDERDCLY EYVPDNVVSM RRIVNTVPIT VRLLQQQQQQ
   421  GDFGGPTPRQ AVAWVVLANQ WPCRLSWALQ CLEDRQQTGG APEGRARLWD VFRDNSRELH
   481  TMTKALQNVL DLDGDPELFE RFLGADFPFT VAEAQSLLRC TVNLDHSIRR RMGLIRAVSA
   541  LKPPSPPKSP TRDTPHAAHR ANSASRAPPS GRASGQAGEG HHTGDLAHRG KLWPVACALF
   601  RPGQSSPGGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skin: 11 nTPM
testis: 1 nTPM
vagina: 0.7 nTPM
breast: 0.5 nTPM
cervix: 0.5 nTPM
prostate: 0.4 nTPM

Single-cell type

late primary spermatocytes: 7.7 nCPM
retinal ganglion cells: 7.7 nCPM
epicardial cells: 6.8 nCPM
epididymal basal cells: 5.3 nCPM
suprabasal keratinocytes: 4.4 nCPM
paneth cells: 3.9 nCPM

Immune cell

naive CD4 T-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 3.5 nTPM
cerebral cortex: 3.2 nTPM
amygdala: 3.1 nTPM
cerebellum: 2.8 nTPM
medulla oblongata: 2.6 nTPM
white matter: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 2.24

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KAP family P-loop domain
KAP family P-loop domain
NTPase KAP P-loop domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKPD1 as an antibody target. Whether an autoantibody or antibody against NKPD1 could matter depends on whether native NKPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKPD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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