Seroatlas · Human Serome Atlas

NKAPL

NKAP-like protein

Also known as: bA424I5.1, C6orf194, NKAPL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5M9Q1
Gene: NKAPL
Ensembl: ENSG00000189134
Chromosome: 6
Canonical length: 402 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q5M9Q1|NKAPL
     1  MPPVSRSSYS EDIVGSRRRR RSSSGSPPSP QSRCSSWDGC SRSHSRGREG LRPPWSELDV
    61  GALYPFSRSG SRGRLPRFRN YAFASSWSTS YSGYRYHRHC YAEERQSAED YEKEESHRQR
   121  RLKERERIGE LGAPEVWGPS PKFPQLDSDE HTPVEDEEEV THQKSSSSDS NSEEHRKKKT
   181  SRSRNKKKRK NKSSKRKHRK YSDSDSNSES DTNSDSDDDK KRVKAKKKKK KKKHKTKKKK
   241  NKKTKKESSD SSCKDSEEDL SEATWMEQPN VADTMDLIGP EAPIIHTSQD EKPLKYGHAL
   301  LPGEGAAMAE YVKAGKRIPR RGEIGLTSEE IGSFECSGYV MSGSRHRRME AVRLRKENQI
   361  YSADEKRALA SFNQEERRKR ESKILASFRE MVHKKTKEKD DK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKAPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
retina: 12 nTPM
skeletal muscle: 5.3 nTPM
heart muscle: 4.7 nTPM
spinal cord: 3.8 nTPM
tongue: 3.7 nTPM

Single-cell type

late primary spermatocytes: 754 nCPM
early spermatids: 295 nCPM
early primary spermatocytes: 110 nCPM
rod photoreceptor cells: 41 nCPM
undifferentiated spermatogonia: 30 nCPM
cone photoreceptor cells: 27 nCPM

Immune cell

plasmacytoid DC: 2.5 nTPM
neutrophil: 2.2 nTPM
eosinophil: 1.6 nTPM
intermediate monocyte: 1.3 nTPM
memory B-cell: 1.3 nTPM
classical monocyte: 1 nTPM

Brain region

pons: 5 nTPM
white matter: 4.5 nTPM
cerebral cortex: 4.3 nTPM
medulla oblongata: 4.2 nTPM
cerebellum: 4.1 nTPM
thalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKAPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CIRSR
HDAC3
RBPJ

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKAPL as an antibody target. Whether an autoantibody or antibody against NKAPL could matter depends on whether native NKAPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKAPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKAPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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