Seroatlas · Human Serome Atlas

NIPAL2

NIPA-like protein 2

Also known as: FLJ13955, NPAL2, NPAL2_HUMAN, SLC57A4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H841
Gene: NIPAL2
Ensembl: ENSG00000104361
Chromosome: 8
Canonical length: 383 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q9H841|NIPAL2
     1  MAAVAPAGPG DSASAALDEL SLNFTYGAPG AGNGSLSGDW YRRNQIHLFG VLLAILGNLV
    61  ISISLNIQKY SHLQLAQQEH PRPYFKSVLW WGGVLLMAVG ETGNFAAYGF APITLIAPLG
   121  CVSVTGSAII SVTFLKDNLR ASDLLGTTLA FAGTYLLVNF APNITQAISA RTVQYYLVGW
   181  QFLIYVILEI LIFCILLYFY KRKGMKHMVI LLTLVAILAS LTVISVKAVS GMITFSVMDK
   241  MQLTYPIFYI MFIIMIASCV FQVKFLNQAT KLYNTTTVVP VNHIFFTISA IIAGIIFYQE
   301  FLGAPFLTVF IYLFGCFLSF LGVFLVTRNR EKEHLQQSYI DFGNIPGKQM LDKIQPDSHS
   361  LSYGTLPDGS DSTKSQSGEK KEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

skin: 50 nTPM
epididymis: 39 nTPM
esophagus: 29 nTPM
ovary: 27 nTPM
cervix: 23 nTPM
rectum: 23 nTPM

Single-cell type

esophageal apical cells: 221 nCPM
somatotrophs: 200 nCPM
prostatic glandular cells: 164 nCPM
thyrotrophs: 157 nCPM
retinal horizontal cells: 156 nCPM
lactotrophs: 156 nCPM

Immune cell

myeloid DC: 3.7 nTPM
eosinophil: 2.9 nTPM
naive B-cell: 2.6 nTPM
classical monocyte: 2 nTPM
T-reg: 2 nTPM
intermediate monocyte: 1.9 nTPM

Brain region

cerebral cortex: 29 nTPM
white matter: 19 nTPM
basal ganglia: 13 nTPM
hypothalamus: 12 nTPM
choroid plexus: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPAL2 as an antibody target. Whether an autoantibody or antibody against NIPAL2 could matter depends on whether native NIPAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPAL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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