Seroatlas · Human Serome Atlas

NIPAL1

Magnesium transporter NIPA3

Also known as: DKFZp686A06115, NIPA3_HUMAN, NPAL1, SLC57A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NVV3
Gene: NIPAL1
Ensembl: ENSG00000163293
Chromosome: 4
Canonical length: 410 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q6NVV3|NIPAL1
     1  MGAQVRLPPG EPCREGYVLS LVCPNSSQAW CEITNVSQLL ASPVLYTDLN YSINNLSISA
    61  NVENKYSLYV GLVLAVSSSI FIGSSFILKK KGLLQLASKG FTRAGQGGHS YLKEWLWWVG
   121  LLSMGAGEAA NFAAYAFAPA TLVTPLGALS VLISAILSSY FLNEHLNIHG KIGCILSILG
   181  STVMVIHAPQ EEEVTSLHEM EMKLRDPGFI SFAVIITVIS LVLILIVAPK KGQTNILVYI
   241  SICSLIGAFS VSSVKGLGIA IKELIEWKPV YKHPLVFVLL AVLVLSVTTQ INYLNKALDT
   301  FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMTAGDIIGT LSGFFTIIIG IFLLHAFKNT
   361  DITWSELTST AKKEAVSLNV NENNYVLLEN LECSAPGYND DVTLFSRTDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skin: 24 nTPM
esophagus: 21 nTPM
liver: 15 nTPM
colon: 13 nTPM
rectum: 13 nTPM
urinary bladder: 7.2 nTPM

Single-cell type

esophageal apical cells: 264 nCPM
rod photoreceptor cells: 260 nCPM
urothelial cells: 198 nCPM
esophageal suprabasal cells: 145 nCPM
renal collecting duct principal cells: 119 nCPM
suprabasal keratinocytes: 107 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 3 nTPM
basal ganglia: 1.4 nTPM
cerebellum: 1.4 nTPM
cerebral cortex: 1.3 nTPM
choroid plexus: 1.3 nTPM
medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

magnesium ion transport

Molecular functions

magnesium ion transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPAL1 as an antibody target. Whether an autoantibody or antibody against NIPAL1 could matter depends on whether native NIPAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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