Seroatlas · Human Serome Atlas

NIPA2

Magnesium transporter NIPA2

Also known as: NIPA2_HUMAN, SLC57A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8Q9
Gene: NIPA2
Ensembl: ENSG00000140157
Chromosome: 15
Canonical length: 360 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q8N8Q9|NIPA2
     1  MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG HAYLKEWLWW
    61  AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS SYFLNERLNL HGKIGCLLSI
   121  LGSTVMVIHA PKEEEIETLN EMSHKLGDPG FVVFATLVVI VALILIFVVG PRHGQTNILV
   181  YITICSVIGA FSVSCVKGLG IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL
   241  DIFNTSIVTP IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
   301  DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV SRRNGNLTAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

tonsil: 40 nTPM
colon: 38 nTPM
duodenum: 37 nTPM
rectum: 37 nTPM
lymph node: 34 nTPM
small intestine: 34 nTPM

Single-cell type

microglia: 47 nCPM
renal connecting tubule cells: 37 nCPM
papillary tip epithelial cells: 35 nCPM
renal collecting duct intercalated cells: 34 nCPM
distal convoluted tubule cells: 32 nCPM
loop of henle epithelial cells: 30 nCPM

Immune cell

plasmacytoid DC: 82 nTPM
memory B-cell: 77 nTPM
basophil: 72 nTPM
naive B-cell: 67 nTPM
non-classical monocyte: 56 nTPM
intermediate monocyte: 56 nTPM

Brain region

choroid plexus: 28 nTPM
midbrain: 24 nTPM
hypothalamus: 24 nTPM
pons: 24 nTPM
thalamus: 23 nTPM
white matter: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

magnesium ion transport

Molecular functions

magnesium ion transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPA2 as an antibody target. Whether an autoantibody or antibody against NIPA2 could matter depends on whether native NIPA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPA2 is annotated at the cell surface, where native NIPA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NIPA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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