NINJ2
Ninjurin-2
Also known as: NINJ2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NZG7
- Gene
- NINJ2
- Ensembl
- ENSG00000171840
- Chromosome
- 12
- Canonical length
- 142 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum,Plasma membrane
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]
Canonical amino-acid sequenceUniProt
142 residues, UniProt reviewed canonical sequence.
>Q9NZG7|NINJ2
1 MESARENIDL QPGSSDPRSQ PINLNHYATK KSVAESMLDV ALFMSNAMRL KAVLEQGPSS
61 HYYTTLVTLI SLSLLLQVVI GVLLVVIARL NLNEVEKQWR LNQLNNAATI LVFFTVVINV
121 FITAFGAHKT GFLAARASRN PLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NINJ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 49 nTPM
- skeletal muscle: 37 nTPM
- bone marrow: 36 nTPM
- lung: 35 nTPM
- midbrain: 29 nTPM
- hippocampal formation: 28 nTPM
Single-cell type
- oligodendrocytes: 173 nCPM
- cardiomyocytes: 127 nCPM
- megakaryocytes: 124 nCPM
- neutrophils: 102 nCPM
- fibro-adipogenic progenitors: 65 nCPM
- kupffer cells: 64 nCPM
Immune cell
- T-reg: 162 nTPM
- neutrophil: 115 nTPM
- classical monocyte: 59 nTPM
- myeloid DC: 51 nTPM
- eosinophil: 49 nTPM
- intermediate monocyte: 48 nTPM
Brain region
- white matter: 74 nTPM
- medulla oblongata: 42 nTPM
- basal ganglia: 42 nTPM
- cerebral cortex: 36 nTPM
- pons: 34 nTPM
- midbrain: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.55
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NINJ2 as an antibody target. Whether an autoantibody or antibody against NINJ2 could matter depends on whether native NINJ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NINJ2 is annotated at the cell surface, where native NINJ2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NINJ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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