Seroatlas · Human Serome Atlas

NINJ1

Ninjurin-1

Also known as: NIN1, NINJ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92982
Gene: NINJ1
Ensembl: ENSG00000131669
Chromosome: 9
Canonical length: 152 aa
Protein class: Predicted membrane proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q92982|NINJ1
     1  MDSGTEEYEL NGGLPPGTPG SPDASPARWG WRHGPINVNH YASKKSAAES MLDIALLMAN
    61  ASQLKAVVEQ GPSFAFYVPL VVLISISLVL QIGVGVLLIF LVKYDLNNPA KHAKLDFLNN
   121  LATGLVFIIV VVNIFITAFG VQKPLMDMAP QQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NINJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 271 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 271 nTPM
adrenal gland: 133 nTPM
parathyroid gland: 129 nTPM
liver: 120 nTPM
kidney: 113 nTPM
urinary bladder: 94 nTPM

Single-cell type

hofbauer cells: 1,041 nCPM
neutrophils: 335 nCPM
monocytes: 279 nCPM
kupffer cells: 274 nCPM
cdc: 244 nCPM
macrophages: 194 nCPM

Immune cell

neutrophil: 1,676 nTPM
eosinophil: 827 nTPM
non-classical monocyte: 358 nTPM
intermediate monocyte: 316 nTPM
classical monocyte: 314 nTPM
total PBMC: 219 nTPM

Brain region

white matter: 64 nTPM
spinal cord: 62 nTPM
thalamus: 60 nTPM
medulla oblongata: 54 nTPM
midbrain: 52 nTPM
pons: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.12
gnomAD missense Z: 1.01
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NINJ1 as an antibody target. Whether an autoantibody or antibody against NINJ1 could matter depends on whether native NINJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NINJ1 is annotated at the cell surface, where native NINJ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NINJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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