NIM1K
Serine/threonine-protein kinase NIM1
Also known as: MGC42105, NIM1, NIM1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IY84
- Gene
- NIM1K
- Ensembl
- ENSG00000177453
- Chromosome
- 5
- Canonical length
- 436 aa
- Protein class
- Enzymes, Predicted membrane proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
436 residues, UniProt reviewed canonical sequence.
>Q8IY84|NIM1K
1 MTAVYMNGGG LVNPHYARWD RRDSVESGCQ TESSKEGEEG QPRQLTPFEK LTQDMSQDEK
61 VVREITLGKR IGFYRIRGEI GSGNFSQVKL GIHSLTKEKV AIKILDKTKL DQKTQRLLSR
121 EISSMEKLHH PNIIRLYEVV ETLSKLHLVM EYAGGGELFG KISTEGKLSE PESKLIFSQI
181 VSAVKHMHEN QIIHRDLKAE NVFYTSNTCV KVGDFGFSTV SKKGEMLNTF CGSPPYAAPE
241 LFRDEHYIGI YVDIWALGVL LYFMVTGTMP FRAETVAKLK KSILEGTYSV PPHVSEPCHR
301 LIRGVLQQIP TERYGIDCIM NDEWMQGVPY PTPLEPFQLD PKHLSETSTL KEEENEVKST
361 LEHLGITEEH IRNNQGRDAR SSITGVYRII LHRVQRKKAL ESVPVMMLPD PKERDLKKGS
421 RVYRGIRHTS KFCSILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NIM1K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 12 nTPM
- basal ganglia: 11 nTPM
- amygdala: 9.6 nTPM
- retina: 9.5 nTPM
- hippocampal formation: 9.1 nTPM
- hypothalamus: 8.1 nTPM
Single-cell type
- cone photoreceptor cells: 149 nCPM
- choroid plexus epithelial cells: 85 nCPM
- ependymal cells: 79 nCPM
- oligodendrocyte progenitor cells: 73 nCPM
- bergmann glia: 71 nCPM
- thyrotrophs: 68 nCPM
Immune cell
- T-reg: 0.8 nTPM
- plasmacytoid DC: 0.3 nTPM
- memory CD4 T-cell: 0.2 nTPM
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebral cortex: 15 nTPM
- basal ganglia: 15 nTPM
- hypothalamus: 13 nTPM
- white matter: 13 nTPM
- thalamus: 12 nTPM
- amygdala: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.09
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Protein kinase domain
- Serine/threonine-protein kinase, active site
- Protein kinase-like domain superfamily
- Protein kinase, ATP binding site
- Protein kinase domain
- Serine/threonine kinase NIM1, catalytic domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NIM1K as an antibody target. Whether an autoantibody or antibody against NIM1K could matter depends on whether native NIM1K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NIM1K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NIM1K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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