Seroatlas · Human Serome Atlas

NICN1

Nicolin-1

Also known as: MGC12936, NICN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSH3
Gene: NICN1
Ensembl: ENSG00000145029
Chromosome: 3
Canonical length: 213 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain, testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9BSH3|NICN1
     1  MSRVLVPCHV KGSVALQVGD VRTSQGRPGV LVIDVTFPSV APFELQEITF KNYYTAFLSI
    61  RVRQYTSAHT PAKWVTCLRD YCLMPDPHSE EGAQEYVSLF KHQMLCDMAR ISELRLILRQ
   121  PSPLWLSFTV EELQIYQQGP KSPSVTFPKW LSHPVPCEQP ALLREGLPDP SRVSSEVQQM
   181  WALTEMIRAS HTSARIGRFD VDGCYDLNLL SYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NICN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 22 nTPM
cerebellum: 21 nTPM
amygdala: 16 nTPM
kidney: 16 nTPM
basal ganglia: 16 nTPM
hippocampal formation: 15 nTPM

Single-cell type

bergmann glia: 3.1 nCPM
brain inhibitory neurons: 2.9 nCPM
brain excitatory neurons: 2.8 nCPM
microglia: 2.8 nCPM
oligodendrocyte progenitor cells: 2.5 nCPM
astrocytes: 2.4 nCPM

Immune cell

T-reg: 6.3 nTPM
non-classical monocyte: 5.4 nTPM
basophil: 5.2 nTPM
memory B-cell: 5.1 nTPM
memory CD8 T-cell: 5.1 nTPM
gdT-cell: 4.3 nTPM

Brain region

cerebral cortex: 25 nTPM
basal ganglia: 24 nTPM
white matter: 23 nTPM
hippocampal formation: 21 nTPM
pons: 20 nTPM
hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.04
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nicolin-1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NICN1 as an antibody target. Whether an autoantibody or antibody against NICN1 could matter depends on whether native NICN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NICN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NICN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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