Seroatlas · Human Serome Atlas

NIBAN3

Protein Niban 3

Also known as: BCNP1, FAM129C, FLJ39802, NIBA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XR2
Gene: NIBAN3
Ensembl: ENSG00000167483
Chromosome: 19
Canonical length: 697 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

No narrative summary is available for NIBAN3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>Q86XR2|NIBAN3
     1  MGPDRKEVPL SRGTQAVVVG KGRGAPGDDS SMGGRPSSPL DKQQRQHLRG QVDTLLRNFL
    61  PCYRGQLAAS VLRQISRELG PQEPTGSQLL RSKKLPRVRE HRGPLTQLRG HPPRWQPIFC
   121  VLRGDGRLEW FSHKEEYENG GHCLGSTALT GYTLLTSQRE YLRLLDALCP ESLGDHTQEE
   181  PDSLLEVPVS FPLFLQHPFR RHLCFSAATR EAQHAWRLAL QGGIRLQGIV LQRSQAPAAR
   241  AFLDAVRLYR QHQGHFGDDD VTLGSDAEVL TAVLMREQLP ALRAQTLPGL RGAGRARAWA
   301  WTELLDAVHA AVLAGASAGL CAFQPEKDEL LASLEKTIRP DVDQLLRQRA RVAGRLRTDI
   361  RGPLESCLRR EVDPQLPRVV QTLLRTVEAS LEAVRTLLAQ GMDRLSHRLR QSPSGTRLRR
   421  EVYSFGEMPW DLALMQTCYR EAERSRGRLG QLAAPFGFLG MQSLVFGAQD LAQQLMADAV
   481  ATFLQLADQC LTTALNCDQA AQRLERVRGR VLKKFKSDSG LAQRRFIRGW GLCIFLPFVL
   541  SQLEPGCKKE LPEFEGDVLA VGSQALTTEG IYEDVIRGCL LQRIDQELKK TLGANDVSCT
   601  LDGCLEVPWE QEGAAPNLNL VSSFLAGRQA FTDFLCLPAK SSANWILAAS LLSCSCFRSG
   661  FHRDSRVFLV QLAEGLSHSL ETVSSHSVWS FRPTPRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIBAN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

spleen: 38 nTPM
lymph node: 24 nTPM
small intestine: 17 nTPM
bone marrow: 15 nTPM
tonsil: 12 nTPM
appendix: 10 nTPM

Single-cell type

pdcs: 505 nCPM
b-cells: 261 nCPM
thymocytes: 47 nCPM
innate lymphoid cells: 9.9 nCPM
breast myoepithelial cells: 9.5 nCPM
retinal amacrine cells: 6.6 nCPM

Immune cell

plasmacytoid DC: 111 nTPM
naive B-cell: 52 nTPM
memory B-cell: 32 nTPM
total PBMC: 2.2 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
pons: 0.3 nTPM
cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIBAN3 as an antibody target. Whether an autoantibody or antibody against NIBAN3 could matter depends on whether native NIBAN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIBAN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIBAN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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