Seroatlas · Human Serome Atlas

NHLRC4

NHL-repeat-containing protein 4

Also known as: NHLC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG21
Gene
NHLRC4
Ensembl
ENSG00000257108
Chromosome
16
Canonical length
123 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

No narrative summary is available for NHLRC4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>P0CG21|NHLRC4
     1  MLGLEGPCWV GPGPDGGLAV SEEFGDVRLF GSARQPLGSL GGWTGHTFGC PAGICSNSEG
    61  NVIVADEQRR QVTLFPRAGP PICLVSEGLG QPLGVACAPQ GQLLVADAKD NSIKVYQGLK
   121  ELA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NHLRC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 11 nTPM
  • kidney: 9.5 nTPM
  • adrenal gland: 5.4 nTPM
  • ovary: 3.7 nTPM
  • spleen: 3.6 nTPM
  • parathyroid gland: 3 nTPM

Single-cell type

  • fallopian tube ciliated cells: 1.9 nCPM
  • thymocytes: 0.8 nCPM
  • basal prostatic cells: 0.6 nCPM
  • respiratory ciliated cells: 0.5 nCPM
  • endometrial ciliated cells: 0.3 nCPM
  • ependymal cells: 0.3 nCPM

Immune cell

  • eosinophil: 2.3 nTPM
  • plasmacytoid DC: 1.7 nTPM
  • memory CD4 T-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • T-reg: 0.5 nTPM
  • memory B-cell: 0.4 nTPM

Brain region

  • midbrain: 6.7 nTPM
  • medulla oblongata: 5.9 nTPM
  • spinal cord: 4.8 nTPM
  • choroid plexus: 4.4 nTPM
  • pons: 2.4 nTPM
  • hypothalamus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.14
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NHLRC4 as an antibody target. Whether an autoantibody or antibody against NHLRC4 could matter depends on whether native NHLRC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NHLRC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NHLRC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NHLRC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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