Seroatlas · Human Serome Atlas

NHLRC3

NHL repeat-containing protein 3

Also known as: NHLC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JS37
Gene: NHLRC3
Ensembl: ENSG00000188811
Chromosome: 13
Canonical length: 347 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a protein containing NCL-1, HT2A and Lin-41 (NHL) family repeats. Mammalian NHL-repeat containing proteins may be involved in a variety of enzymatic processes, including protein modification through ubiquitination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q5JS37|NHLRC3
     1  MARFWVCVAG AGFFLAFLVL HSRFCGSPVL RNFTFAVSWR TEKILYRLDV GWPKHPEYFT
    61  GTTFCVAVDS LNGLVYIGQR GDNIPKILVF TEDGYFLRAW NYTVDTPHGI FAASTLYEQS
   121  VWITDVGSGF FGHTVKKYSS FGDLVQVLGT PGKKGTSLNP LQFDNPAELY VEDTGDIYIV
   181  DGDGGLNNRL IKLSQDFMIL WLHGENGTGP AKFNIPHSVT LDSAGRVWVA DRGNKRIQVF
   241  DKDTGEWLGA WNNCFTEEGP SSVRFTPDGK YLIVAQLNLS RLSVVAAPPV GSIGECSVIS
   301  TIQLADQVLP HLLEVDRKTG AVYVAEIGAK QVQKYVPLNS YVPSFGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NHLRC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

liver: 24 nTPM
epididymis: 19 nTPM
placenta: 18 nTPM
adipose tissue: 17 nTPM
stomach: 16 nTPM
thyroid gland: 16 nTPM

Single-cell type

oligodendrocytes: 133 nCPM
sertoli cells: 124 nCPM
cytotrophoblasts: 107 nCPM
adipocytes: 104 nCPM
decidual stromal cells: 94 nCPM
epididymal principal cells: 90 nCPM

Immune cell

intermediate monocyte: 6.9 nTPM
classical monocyte: 6.8 nTPM
non-classical monocyte: 6.8 nTPM
myeloid DC: 6 nTPM
plasmacytoid DC: 5.4 nTPM
MAIT T-cell: 5.1 nTPM

Brain region

medulla oblongata: 17 nTPM
white matter: 17 nTPM
choroid plexus: 16 nTPM
thalamus: 14 nTPM
spinal cord: 14 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NHLRC3 as an antibody target. Whether an autoantibody or antibody against NHLRC3 could matter depends on whether native NHLRC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NHLRC3 is annotated as secreted, so native NHLRC3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NHLRC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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