Seroatlas · Human Serome Atlas

NGB

Neuroglobin

Also known as: NGB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPG2
Gene: NGB
Ensembl: ENSG00000165553
Chromosome: 14
Canonical length: 151 aa
Protein class: Predicted intracellular proteins, Transporters
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>Q9NPG2|NGB
     1  MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE
    61  FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC
   121  LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NGB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 75 nTPM
cerebral cortex: 34 nTPM
pituitary gland: 18 nTPM
amygdala: 9.6 nTPM
adrenal gland: 7.6 nTPM
colon: 5.7 nTPM

Single-cell type

other brain neurons: 38 nCPM
oocytes: 14 nCPM
adrenal medulla cells: 11 nCPM
oligodendrocyte progenitor cells: 10 nCPM
thymocytes: 9.3 nCPM
brain excitatory neurons: 7.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 108 nTPM
thalamus: 60 nTPM
pons: 45 nTPM
midbrain: 42 nTPM
medulla oblongata: 34 nTPM
cerebral cortex: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NGB as an antibody target. Whether an autoantibody or antibody against NGB could matter depends on whether native NGB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NGB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NGB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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