Seroatlas · Human Serome Atlas

NFILZ

NFIL3 like protein

Also known as: LINC01862, NFILZ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A5F9ZHS7
Gene
NFILZ
Ensembl
ENSG00000268480
Chromosome
19
Canonical length
289 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in circadian rhythm and regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>A0A5F9ZHS7|NFILZ
     1  MDVGFSGLPD VSQSHSKTLW GARGRGPSIR RQREFMPEEK KDTVYWEKRR KNNEAAKRSR
    61  EKRRLNDAAI EGRLAALMEE NALLKGELKA LKLRFGLLPL TGGPRALPLQ ALLLEAPWTG
   121  DPRPGAEALS SLSGSHSCLL RPRSLDAGIP GCRGCLLAPR WTGLATSPRS PQESASPTLN
   181  RIDMALQTAL PPALFSCHLL EGHVGSRPEL RPCWGLWSPV PSGCRASGPS DVLLTPTADP
   241  MGLSPGVTCP APGNSPEGLG QPSLPHKLRI KSRASGRVPR GWEGGQAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFILZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
1.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.5 nTPM
  • bone marrow: 0.7 nTPM
  • retina: 0.5 nTPM
  • skeletal muscle: 0.4 nTPM
  • skin: 0.4 nTPM
  • spleen: 0.3 nTPM

Single-cell type

  • late spermatids: 329 nCPM
  • early spermatids: 86 nCPM
  • innate lymphoid cells: 7.7 nCPM
  • pericytes: 5.9 nCPM
  • thymocytes: 5.9 nCPM
  • late primary spermatocytes: 3.8 nCPM

Immune cell

  • NK-cell: 15 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • gdT-cell: 0.6 nTPM
  • neutrophil: 0.6 nTPM
  • basophil: 0.5 nTPM
  • memory CD4 T-cell: 0.2 nTPM

Brain region

  • white matter: 11 nTPM
  • cerebellum: 11 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 11 nTPM
  • thalamus: 11 nTPM
  • midbrain: 11 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFILZ as an antibody target. Whether an autoantibody or antibody against NFILZ could matter depends on whether native NFILZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFILZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFILZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NFILZ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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