Seroatlas · Human Serome Atlas

NEUROG2

Neurogenin-2

Also known as: Atoh4, bHLHa8, Math4A, ngn-2, NGN2, NGN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2A3
Gene: NEUROG2
Ensembl: ENSG00000178403
Chromosome: 4
Canonical length: 272 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q9H2A3|NEUROG2
     1  MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG
    61  QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR
   121  ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG
   181  LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP
   241  ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEUROG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 2.1 nTPM
hippocampal formation: 2 nTPM
cerebellum: 1.8 nTPM
amygdala: 1.5 nTPM
testis: 1.5 nTPM
cerebral cortex: 0.5 nTPM

Single-cell type

müller glia: 8.4 nCPM
breast myoepithelial cells: 6 nCPM
late primary spermatocytes: 2.9 nCPM
early spermatids: 2 nCPM
late spermatids: 1.6 nCPM
brain inhibitory neurons: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 7.1 nTPM
cerebral cortex: 4.4 nTPM
basal ganglia: 2.7 nTPM
cerebellum: 2.7 nTPM
amygdala: 1.9 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.81
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Myc-type, basic helix-loop-helix (bHLH) domain
Helix-loop-helix DNA-binding domain superfamily
Basic helix-loop-helix transcription factors
Helix-loop-helix DNA-binding domain
Neurogenin-2, basic helix-loop-helix domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEUROG2 as an antibody target. Whether an autoantibody or antibody against NEUROG2 could matter depends on whether native NEUROG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEUROG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEUROG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...