NEUROG1

Protein identityUniProt · HPA

UniProt accession

Q92886

Gene

NEUROG1

Ensembl

ENSG00000181965

Chromosome

5

Canonical length

237 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q92886|NEUROG1
     1  MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE
    61  VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP
   121  SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA
   181  SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEUROG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

0.7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NEUROG1.

Disease | AllUniProt

Conditions NEUROG1 is implicated in, by any mechanism.

• Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay (CCDDRD) MIM:620469

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay
• See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.89

gnomAD pLI

0

gnomAD missense Z

-0.8

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• auditory behavior
• axon development
• cell fate commitment
• cochlea development
• cochlea morphogenesis
• craniofacial suture morphogenesis
• exit from mitosis
• forebrain development
• genitalia development
• genitalia morphogenesis
• hard palate morphogenesis
• inner ear development
• inner ear morphogenesis
• learned vocalization behavior
• mastication
• negative regulation of relaxation of muscle
• negative regulation of saliva secretion
• nervous system development
• neuromuscular process controlling balance
• peristalsis
• positive regulation of DNA-binding transcription factor activity
• positive regulation of exit from mitosis
• positive regulation of neuron differentiation
• positive regulation of transcription by RNA polymerase II
• regulation of muscle organ development
• regulation of transcription by RNA polymerase II
• sensory organ development
• thorax and anterior abdomen determination
• trigeminal nerve development
• vestibulocochlear nerve formation

Molecular functions

• chromatin binding
• DNA binding
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• E-box binding
• protein homodimerization activity
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus
• perikaryon

Protein domainsUniProt · Pfam · InterPro

• Myc-type, basic helix-loop-helix (bHLH) domain
• Helix-loop-helix DNA-binding domain superfamily
• Basic helix-loop-helix transcription factors
• Helix-loop-helix DNA-binding domain

KeywordsUniProt

• Activator
• Deafness
• Developmental protein
• Differentiation
• DNA-binding
• Intellectual disability
• Neurogenesis
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of NEUROG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TCF4