Seroatlas · Human Serome Atlas

NEUROD6

Neurogenic differentiation factor 6

Also known as: Atoh2, bHLHa2, Math-2, NDF6_HUMAN, Nex1, NEX1M

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NK8
Gene: NEUROD6
Ensembl: ENSG00000164600
Chromosome: 7
Canonical length: 337 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q96NK8|NEUROD6
     1  MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR APGEETEKEE
    61  EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV
   121  VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC
   181  LQLNARSFLM GQGGEAAHHT RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY
   241  ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
   301  GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEUROD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 39 nTPM
cerebral cortex: 31 nTPM
amygdala: 11 nTPM
cerebellum: 5.1 nTPM
midbrain: 0.9 nTPM
hypothalamus: 0.5 nTPM

Single-cell type

brain excitatory neurons: 23 nCPM
gastric chief cells: 2.2 nCPM
oligodendrocytes: 1.4 nCPM
astrocytes: 1 nCPM
microglia: 1 nCPM
ependymal cells: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 51 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 20 nTPM
white matter: 13 nTPM
amygdala: 5.5 nTPM
cerebellum: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.88
gnomAD missense Z: 1.84
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEUROD6 as an antibody target. Whether an autoantibody or antibody against NEUROD6 could matter depends on whether native NEUROD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEUROD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEUROD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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