Seroatlas · Human Serome Atlas

NEUROD4

Neurogenic differentiation factor 4

Also known as: ATH-3, Atoh3, bHLHa4, MATH-3, NDF4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HD90
Gene: NEUROD4
Ensembl: ENSG00000123307
Chromosome: 12
Canonical length: 331 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in neuron differentiation; positive regulation of cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Notch signaling pathway; cell fate commitment; and neurogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q9HD90|NEUROD4
     1  MSKTFVKSKE MGELVNTPSW MDKGLGSQNE VKEEESRPGT YGMLSSLTEE HDSIEEEEEE
    61  EEDGEKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM HGLNDALDNL RRVMPCYSKT
   121  QKLSKIETLR LARNYIWALS EVLETGQTPE GKGFVEMLCK GLSQPTSNLV AGCLQLGPQS
   181  VLLEKHEDKS PICDSAISVH NFNYQSPGLP SPPYGHMETH LLHLKPQVFK SLGESSFGSH
   241  LPDCSTPPYE GPLTPPLSIS GNFSLKQDGS PDLEKSYSFM PHYPSSSLSS GHVHSTPFQA
   301  GTPRYDVPID MSYDSYPHHG IGTQLNTVFT E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEUROD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

retina: 28 nTPM
pituitary gland: 7.7 nTPM
adrenal gland: 1.7 nTPM
choroid plexus: 1.1 nTPM
cerebral cortex: 0.2 nTPM
testis: 0.2 nTPM

Single-cell type

retinal bipolar cells: 172 nCPM
gonadotrophs: 88 nCPM
lactotrophs: 50 nCPM
somatotrophs: 47 nCPM
thyrotrophs: 32 nCPM
retinal horizontal cells: 6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.3 nTPM
choroid plexus: 1.2 nTPM
cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM
spinal cord: 0.1 nTPM
thalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.1
gnomAD missense Z: -0.57
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEUROD4 as an antibody target. Whether an autoantibody or antibody against NEUROD4 could matter depends on whether native NEUROD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEUROD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEUROD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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