Seroatlas · Human Serome Atlas

NETO2

Neuropilin and tolloid-like protein 2

Also known as: FLJ10430, NEOT2, NETO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC67
Gene: NETO2
Ensembl: ENSG00000171208
Chromosome: 16
Canonical length: 525 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q8NC67|NETO2
     1  MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP
    61  NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR
   121  YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE
   181  LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA
   241  VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS
   301  TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV
   361  LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD
   421  NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK
   481  SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NETO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spleen: 21 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 12 nTPM
cerebellum: 11 nTPM
parathyroid gland: 10 nTPM
choroid plexus: 9.4 nTPM

Single-cell type

retinal pigment epithelial cells: 230 nCPM
brain inhibitory neurons: 204 nCPM
monocyte progenitors: 97 nCPM
müller glia: 93 nCPM
oligodendrocyte progenitor cells: 92 nCPM
monocytes: 88 nCPM

Immune cell

classical monocyte: 0.9 nTPM
myeloid DC: 0.6 nTPM
intermediate monocyte: 0.5 nTPM
T-reg: 0.5 nTPM
non-classical monocyte: 0.4 nTPM
basophil: 0.3 nTPM

Brain region

basal ganglia: 57 nTPM
cerebral cortex: 35 nTPM
hypothalamus: 32 nTPM
pons: 31 nTPM
white matter: 24 nTPM
cerebellum: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.06
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ionotropic glutamate receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NETO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NETO2 as an antibody target. Whether an autoantibody or antibody against NETO2 could matter depends on whether native NETO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NETO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NETO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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