Seroatlas · Human Serome Atlas

NEMP2

Nuclear envelope integral membrane protein 2

Also known as: NEMP2_HUMAN, TMEM194B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFY4
Gene: NEMP2
Ensembl: ENSG00000189362
Chromosome: 2
Canonical length: 417 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>A6NFY4|NEMP2
     1  MGPRQGRWWL LLWLPPLATL PVRGEAAAAA LSVRRCKALK EKDLIRTSES DCYCYNQNSQ
    61  VEWKYIWSTM QVKITSPGLF RIVYIAERHN CQYPENILSF IKCVIHNFWI PKESNEITII
   121  INPYRETVCF SVEPVKKIFN YMIHVNRNIM DFKLFLVFVA GVFLFFYART LSQSPTFYYS
   181  SGTVLGVLMT LVFVLLLVKR FIPKYSTFWA LMVGCWFASV YIVCQLMEDL KWLWYENRIY
   241  VLGYVLIVGF FSFVVCYKHG PLADDRSRSL LMWMLRLLSL VLVYAGVAVP QFAYAAIILL
   301  MSSWSLHYPL RACSYMRWKM EQWFTSKELV VKYLTEDEYR EQADAETNSA LEELRRACRK
   361  PDFPSWLVVS RLHTPSKFAD FVLGGSHLSP EEISLHEEQY GLGGAFLEEQ LFNPSTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

thymus: 4.3 nTPM
lymph node: 3.4 nTPM
testis: 2.8 nTPM
tonsil: 2.8 nTPM
appendix: 2.3 nTPM
cerebellum: 2.3 nTPM

Single-cell type

epicardial cells: 41 nCPM
thymocytes: 29 nCPM
late primary spermatocytes: 23 nCPM
cardiomyocytes: 22 nCPM
monocyte progenitors: 17 nCPM
nk-cells: 17 nCPM

Immune cell

T-reg: 3.1 nTPM
naive CD4 T-cell: 2.7 nTPM
naive CD8 T-cell: 2.3 nTPM
MAIT T-cell: 2 nTPM
naive B-cell: 1.9 nTPM
plasmacytoid DC: 1.9 nTPM

Brain region

cerebellum: 8.8 nTPM
white matter: 6 nTPM
basal ganglia: 5.2 nTPM
cerebral cortex: 5.2 nTPM
pons: 5.2 nTPM
thalamus: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEMP2 as an antibody target. Whether an autoantibody or antibody against NEMP2 could matter depends on whether native NEMP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEMP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEMP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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