Seroatlas · Human Serome Atlas

NEMP1

Nuclear envelope integral membrane protein 1

Also known as: KIAA0286, NEMP1_HUMAN, TMEM194, TMEM194A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14524
Gene: NEMP1
Ensembl: ENSG00000166881
Chromosome: 12
Canonical length: 444 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

Involved in nuclear membrane organization. Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>O14524|NEMP1
     1  MAGGMKVAVS PAVGPGPWGS GVGGGGTVRL LLILSGCLVY GTAETDVNVV MLQESQVCEK
    61  RASQQFCYTN VLIPKWHDIW TRIQIRVNSS RLVRVTQVEN EEKLKELEQF SIWNFFSSFL
   121  KEKLNDTYVN VGLYSTKTCL KVEIIEKDTK YSVIVIRRFD PKLFLVFLLG LMLFFCGDLL
   181  SRSQIFYYST GMTVGIVASL LIIIFILSKF MPKKSPIYVI LVGGWSFSLY LIQLVFKNLQ
   241  EIWRCYWQYL LSYVLTVGFM SFAVCYKYGP LENERSINLL TWTLQLMGLC FMYSGIQIPH
   301  IALAIIIIAL CTKNLEHPIQ WLYITCRKVC KGAEKPVPPR LLTEEEYRIQ GEVETRKALE
   361  ELREFCNSPD CSAWKTVSRI QSPKRFADFV EGSSHLTPNE VSVHEQEYGL GSIIAQDEIY
   421  EEASSEEEDS YSRCPAITQN NFLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

thymus: 15 nTPM
lymph node: 11 nTPM
tonsil: 11 nTPM
skin: 10 nTPM
retina: 8.6 nTPM
colon: 8.2 nTPM

Single-cell type

erythrocyte progenitors: 52 nCPM
monocyte progenitors: 43 nCPM
epididymal basal cells: 39 nCPM
podocytes: 38 nCPM
cdc: 35 nCPM
early primary spermatocytes: 33 nCPM

Immune cell

basophil: 2.4 nTPM
NK-cell: 2.4 nTPM
memory B-cell: 1.9 nTPM
naive CD4 T-cell: 1.8 nTPM
naive B-cell: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM

Brain region

white matter: 6.5 nTPM
choroid plexus: 5.6 nTPM
medulla oblongata: 5.5 nTPM
cerebellum: 5.4 nTPM
basal ganglia: 5.1 nTPM
amygdala: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.92
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EMD
RAN-GTP
RAN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEMP1 as an antibody target. Whether an autoantibody or antibody against NEMP1 could matter depends on whether native NEMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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