Seroatlas · Human Serome Atlas

NEGR1

Neuronal growth regulator 1

Also known as: IGLON4, KILON, MGC46680, NEGR1_HUMAN, Ntra

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3B1
Gene: NEGR1
Ensembl: ENSG00000172260
Chromosome: 1
Canonical length: 354 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Vesicles,Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to be involved in cell adhesion and regulation of synapse assembly. Predicted to act upstream of or within several processes, including cholesterol homeostasis; lipid droplet formation; and nervous system development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q7Z3B1|NEGR1
     1  MDMMLLVQGA CCSNQWLAAV LLSLCCLLPS CLPAGQSVDF PWAAVDNMMV RKGDTAVLRC
    61  YLEDGASKGA WLNRSSIIFA GGDKWSVDPR VSISTLNKRD YSLQIQNVDV TDDGPYTCSV
   121  QTQHTPRTMQ VHLTVQVPPK IYDISNDMTV NEGTNVTLTC LATGKPEPSI SWRHISPSAK
   181  PFENGQYLDI YGITRDQAGE YECSAENDVS FPDVRKVKVV VNFAPTIQEI KSGTVTPGRS
   241  GLIRCEGAGV PPPAFEWYKG EKKLFNGQQG IIIQNFSTRS ILTVTNVTQE HFGNYTCVAA
   301  NKLGTTNASL PLNPPSTAQY GITGSADVLF SCWYLVLTLS SFTSIFYLKN AILQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEGR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 31 nTPM
retina: 28 nTPM
colon: 16 nTPM
adipose tissue: 16 nTPM
blood vessel: 15 nTPM
cerebellum: 13 nTPM

Single-cell type

fibro-adipogenic progenitors: 4,285 nCPM
leydig cells: 2,588 nCPM
thyrotrophs: 2,373 nCPM
rod photoreceptor cells: 2,355 nCPM
brain excitatory neurons: 1,921 nCPM
corticotrophs: 1,721 nCPM

Immune cell

myeloid DC: 0.8 nTPM
plasmacytoid DC: 0.8 nTPM
basophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

basal ganglia: 54 nTPM
cerebral cortex: 54 nTPM
hypothalamus: 47 nTPM
white matter: 35 nTPM
midbrain: 34 nTPM
hippocampal formation: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 0.99
gnomAD missense Z: 1.64
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane transporter binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEGR1 as an antibody target. Whether an autoantibody or antibody against NEGR1 could matter depends on whether native NEGR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEGR1 is annotated at the cell surface, where native NEGR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NEGR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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